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Inventi Impact: Obstetrics and Gynaecology

Articles

  • Inventi:hsr/18366/15
    Resveratrol, Acetyl-resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell\nAggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines
    01-Jan-1970 Research 2016 : January - March
    Simon J Hogg, Kenny Chitcholtan, Wafaa Hassan, Peter H Sykes, Ashley Garrill

    Resveratrol has aroused significant scientific interest as it has been claimed that it exhibits a spectrum of health benefits. These\ninclude effects as an anti-inflammatory and an antitumour compound.The purpose of this study was to investigate and compare\nany potential antigrowth effects of resveratrol and two of its derivatives, acetyl-resveratrol and polydatin, on 3D cell aggregates of\nthe EGFR/Her-2 positive and negative ovarian cancer cell lines SKOV-3 andOVCAR-8, respectively. Results showed that resveratrol\nand acetyl-resveratrol reduced cell growth in the SKOV-3 and OVCAR-8 in a dose-dependant manner.The growth reduction was\nmediated by the induction of apoptosis via the cleavage of poly(ADP-ribose) polymerase (PARP-1). At lower concentrations, 5 and\n10

    How to Cite this Article
    CC Compliant Citation: Simon J. Hogg, Kenny Chitcholtan, Wafaa Hassan, Peter H. Sykes, and Ashley Garrill, â??Resveratrol, Acetyl-Resveratrol,\nand Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines,â? Obstetrics and\nGynecology International, vol. 2015, Article ID 279591, 14 pages, 2015. doi:10.1155/2015/279591, http://creativecommons.org/licenses/\nby/3.0/.
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